Pathophysiological Effects of Lyso-Glycerophospholipids

Lyso-PtdCho is not simply a lipid metabolite producing neurotrophic and neurotoxic effects. It participates in many signal transduction processes. Lyso-PtdCho activates protein kinases such as protein kinase C, protein kinase A, and c-jun terminal kinase. Lyso-PtdCho stimulates phospholipase D and inhibits CTP-phosphocholine cytidylyltransferase (Gomez-Munoz et al., 1999 Boggs et al., 1995). Lyso-PtdCho acts as an agonist for certain G-protein coupled receptors and can be converted to another bioactive lipid, lyso-phosphatidic acid. 

5 Excitatory Amino Acid Receptors and Neural Membrane 

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