Pathogen Sensing Using NA Hybridization

No target present High SERS signal Open Nanoprobe Target present Low SERS signal 

Kang and co-workers developed a Au NP-on-wire SERS sensor for multiplex pathogen DNA detection (Kang et al. 2010). The sensor is illustrated in Fig. 7.3. Au NWs (150 nm diameter) were functionalized with thiolated captured sequences on the Si substrate and incubated with target sequences. Then, such functionalized Au 

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