PasteureUa multocida

McFarland JW, Berger CM, Froshauer SA, Hayadii SF, Hecker SJ, Jaynes BH, Jefson MR, Kamicker BJ, Lipinski CA, Limdy KM, Reese CP and Vu CB, Quantitative Structure-activity relationships among macrolide antibacterial agents In vitro and in vivo potency against PasteureUa multocida, /. Med. Chem., 40,1340-1346 (1997). 

Besides the skin, gut, and BBB, there are other coculture models exhibiting crosstalk between the cocultured cell types that were developed for measuring toxicity. For example, an epitheHal/fibroblast [Lang et al., 1998] coculture model of the bronchial epithelial was used to examine ozone toxicity. Bone resorption caused by PasteureUa multocida toxin was studied in an osteoclast/osteoblast direct contact coculture model [MuUan and Lax, 1998]. Brana et al. [1999] cultured 400-/um thick rat brain (hippocampal) slices on a membrane insert and cultured the murine macrophage cell line (RAW 264.7) underneath. When challenged with the HIV-1 derived Tat protein, neuronal cell death in the brain slice occurred only when cocultured with the macrophage cell line. This model could be used to identify neurotoxic soluble molecules released by macrophages. 

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