Particuliarities and Limitations of Mass Spectrometry

As for any other method, particular effects connected to the transition from solution to the gas phase and limitations arising from the mass spectrometric technique need to be considered for mass spectrometric experiments vith supramolecules in order to avoid misinterpretations. 

When comparing gas-phase data with condensed-phase results, the influence of a charge cannot be neglected. Consequently, a comparison of e.g. neutral dimeric complexes in solution with proton-bridged dimers in the gas phase almost unavoidably leads to misinterpretation. 

Beyond Analytical Characterization Tandem MS Experiments for the Examination of the Cas-phase Chemistry of Supramolecules 

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