Particle size progesterone

Further examples for of importance of particle size on the absorption of lipophilic drugs have been described for griseofulvin [21] and progesterone [22]. 

Hargrove, J.T., W.S. Maxson, and A.C. Wentz. 1989. Absorption of oral progesterone is influenced by vehicle and particle size. Am J Obstet Gynecol 161 948. 

Incorporation of the steroidal drugs hydrocortisone and progesterone in complex with p-CD and HP-P-CD reduced the particle size for solid lipid nanoparticles (SLNs) below lOOnm. Steroids were demonstrated to be dispersed in the amorphous state. Compexation to CDs resulted in higher drug-loading properties for the more hydrophobic drug hydrocortisone and lower in vitro release for both drugs when they are complexed to CDs rather than their free form [31]. 

LS containing hydrophobic retinyl acetate were yellow (because of the color of the drug) and spherical, with a slightly waved surface (Figure 2.7) and a narrow size distribution (184 6.6 pm). Particles containing progesterone were very similar in shape (data not shown) and were white (mean diameter, 192 11.6 pm). 

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