Particle size flow rate and

As we discussed above, efficiency and selectivity are complementary descriptors dependent on the different sets of chromatographic parameters. Efficiency is more dependent on the quality of the column packing, particle size, flow rate, and instrumental optimization, while selectivity is more dependent on the stationary phase properties and the nature of the analytes themselves. However, efficiency is sometimes affected by nonideal interactions of the analyte with the stationary phase (i.e., peak tailing). 

The pattern of deposition of inhaled particles in a normal lung is dependent on particle size, flow rate, and airway anatomy (branching). There are also patient specific variables that influence aerosol deposition. These include respiratory rate, tidal volume, and other anatomical features. The presence of airflow obstruction characteristic of some lung diseases will affect deposition. 

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