Particle-beam interface disadvantages

LC-MS inlet probes support all conventional HPLC column diameters from mobile phase must be eliminated, either before entering or from inside the mass spectrometer, so that the production of ions is not adversely affected. The problem of removing the solvent is usually overcome by direct-liquid-introduction (DLI), mechanical transport devices, or particle beam (PB) interfaces. The main disadvantages of transport devices are that column... 

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