Pars compacta glucose utilization

Fig. 14. Caudate nucleus (A), and nucleus accumbens (B), substantia nigra, pars compacta (C), and substantia nigra, pars reticulata (D). Log dose-response curves of glucose utilization folloiving the intravenous administration of apomorphine. Data are presented as means SEM. (From McCulloch et al, 198Id.)...

Fig. 15. Substantia nigra, pars compacta. Metabolic response to apomorphine (0.5 mg/kg) (expressed as percent change in cerebral glucose utilization from control animals) in four groups of animals which had been pretreated for 21 days with saline (SAL), haloperidol (HAL) (1 mg/kg/day), haloperidol with lithium in diet (Li /HAL), and lithium in diet (Li" ). Data are presented as mean SEM. The response to apomorphine in the animal chronically treated with haloperidol (HAL) differs significantly from that with all other treatments. Glucose utilization in control animals was 56 4 pmol/100 g/ min. (Data from McCulloch, Savaki, Pert, Bunney, and Sokoloff, unpublished.)...

Fig. 17. Representative autoradiographs of the ventral mesencephalon. The relative rates of glucose utilization are related directly to relative optical densities. (A) Conscious, saline treated. The pars compacta can be identified as a well-defined line of relatively increased optical density. (B) Conscious, apomorphine treated. The pars compacta and pars reticulata each display marked increases in relative optical density. (C) Chloral hydrate anesthesia, saline treated. Glucose use in the pars compacta is minimally reduced by anesthesia and remains a well-defined band of optical density. (D) Chloral hydrate anesthesia, apomorphine treated. Glucose use in the pars compacta is reduced, and optical density in the pars compacta is no longer different from that in the adjacent pars reticulata. (From Grome and McCulloch 1981a).

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