Parenteral preparations biopharmaceutics

Figure 3.29. Photographic representation of a blow-fill-seal machine, which can be particularly useful in the aseptic filling of liquid products (refer to text for details). While used fairly extensively in facilities manufacturing some traditional parenteral products, this system has not yet found application in biopharmaceutical manufacture. This is due mainly to the fact that many biopharmaceutical preparations are sold not in liquid, but in freeze-dried format. Also, some proteins display a tendancy to adsorb onto plastic surfaces. Photo courtesy of Rommelag a.g., Switzerland...

Lyophiiization as a parenteral process began in the early twentieth century as a way to prepare pharmaceutical products that are unstable in liquid form. In the 1980s and with the birth of biopharmaceutical development, the need to store products that were not stable in a liquid format increased. The process of freeze-drying these types of products became much more common. Currently there are more than 100 lyophilized products in the market in the United States alone. 

Biotechnology of Antibiotics Second Edition, Revised and Expanded, edited by William R Strohl 83. Mechanisms of Transdermal Dmg Delivery, edited by Russell 0. Potts and Richard H. Guy 84. Pharmaceutical Enzymes, edited by Albert Lauwers and Simon Scharpe 85. Development of Biopharmaceutical Parenteral Dosage Forms, edited by John A. Bontempo ADDITIONAL VOLUMES IN PREPARATION Pharmaceutical Project Management, edited by Anthony Kennedy... 

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