Propafenone Parecoxib

PROPAFENONE NS AIDS Serum levels of propafenone may be t by parecoxib Parecoxib is a weak inhibitor of CYP2D6-mediated metabolism of propafenone Monitor PR and BP closely. If possible, use only short courses of NS AID... 

As parecoxib is rapidly metabolised to valdecoxib, the interactions are usually considered to be due to the effects of valdecoxib. The manufacturer of parecoxib cautions the concurrent use with carbamazepine, dexamethasone and rifampicin as their effects on parecoxib have not been studied. Valdecoxib increases the levels of dextromethorphan and omeprazole. Because of these interactions, caution is advised with drugs that are metabolised by the same isoenzymes, nameiy flecainide, metoprolol, propafenone, omeprazoie, diazepam, imipramine and phenytoin. No interaction appears to occur between parecoxib and midazolam. 

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See also in sourсe #XX -- [ ]

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