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Paramagnetism-based structural restraints

In the presence of a paramagnetic species, pseudocontact shifts can provide additional restraints since these shifts are both distance and orientation dependent. Gaponenko et a/. have attached a Co + paramagnetic probe to the N-terminal domain of the protein STAT4. The attachment is achieved by modifying a cysteine residue into a thiol-reactive chelator. With the additional restraints derived from pseudocontact shifts, the NMR structures are improved based on the rmsd value of the family of structures obtained. This approach is likewise illustrated in the work of Barbieri et on the protein Calbindin D9k. Here, the ions employed are Ce, Yb " , and Dy ". ... [Pg.75]

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See also in sourсe #XX -- [ Pg.84 ]



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