Paralysis agitans

Tablets Used as an anticholinergic CNS depressant in the symptomatic treatment of postencephalitic parkinsonism and paralysis agitans in spastic states and locally as a substitute for atropine in ophthalmology.

Treatment of symptoms of idiopathic Parkinson s disease (paralysis agitans), postencephalitic parkinsonism, and sympathetic parkinsonism that may follow injury to the nervous system by carbon monoxide and manganese intoxication. 

Nukada H, Kowa H, Saitoh T, Tazaki Y, Miura S (1978) [A big family of paralysis agitans (author s transl)]. Rinsho Shinkeigaku 18 627-634... 

James Parkinson (1755-1824), physician he described paralysis agitans in 1817. 

Certain drugs with anticholinergic effects are used for the symptomatic treatment of Parkinson s disease (paralysis agitans) and related syndromes of the extrapyramidal tracts. (Of the presently available drugs, none is useful in all cases of Parkinsonism.) Despite claims of superiority for newly introduced synthetic agents, none possesses outstanding efficacy and freedom from adverse side effects when compared clinically with atropine and scopolamine (241). 

Dr James Parkinson first described this disease in 1817 as paralysis agitans or the shaking palsy. Parkinson s disease is the second most common neurodegenerative disease after Alzheimer s disease, affecting 2% of the population over the age of 65. 

Its centrally potent actions are used in various conditions, namely postencephphalitic parkinsonism, paralysis agitans, respiratory stimulation, some types of spastic and rigid states and rarely in schizophrenia at its toxic dose level). 

Parkinson s disease or Paralysis agitans was first described as early as 1817 by James Parkinson, a London doctor, as consisting essentially of Involuntary tremulous motion with decreased muscular power in parts not in action and even when supported, with a propensity to bend the trunk forwards and to pass from a walking to a running pace, the senses and intellect being uninjured . 

Hallervorden, J. Spatform der amaurotischen Idiotie unter dem Bilde der Paralysis agitans. Mschr. Psychiat. Neurol. 99, 74 (1938). 

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