Paracetamol separation from mixtures

The product is a mixture of ortho- and para-nitrophenol from which the ortho compound can be separated by steam distillation. A strong intramolecular hydrogen bond reduces the availability of the OH group for intermolecular hydrogen bonds so the ortho compound has a lower boiling point. The remaining pnra-nitrophenol is used in the manufacture of the painkiller paracetamol. [Pg.568]

Figure 18-12. Separation of test mixture and fractions after extraction and trapping and sequential elution at increasing temperatures. Separation on PS-DVB column at 75-185°C at 15°C/min. Analytes 1, paracetamol 2, salicylamide 3, caffeine 4, methyl paraben 5, phenacetin 6, ethyl paraben. Separations a, direct injection of original mixture of 1-6 without trapping b, fraction untrapped at ambient temperature c, fraction released from trap at 70°C d, released at 90°C e, released at 110°C. (Reproduced from reference 76, with permission from Royal Society of Chemistry.)...

$Figure 18-12. Separation of test mixture and fractions after extraction and trapping and sequential elution at increasing temperatures. Separation on PS-DVB column at 75-185°C at 15°C/min. Analytes 1, paracetamol 2, salicylamide 3, caffeine 4, methyl paraben 5, phenacetin 6, ethyl paraben. Separations a, direct injection of original mixture of 1-6 without trapping b, fraction untrapped at ambient temperature c, fraction released from trap at 70°C d, released at 90°C e, released at 110°C. (Reproduced from reference 76, with permission from Royal Society of Chemistry.)...$

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