Paracetamol retrosynthetic analysis

Which reagent is best can often only be determined by experimentation—commercially, paracetamol is made from para-aminophenol and acetic anhydride largely because the by-product, acetic acid, is easier to handle than HC1. In a retrosynthetic analysis, we don t really want to be bothered by this sort of decision, which is best made later, so it s useful to have a single way of representing the key attributes of alternative reagents. We can depict both anhydride and acyl chloride in this scheme as an idealized reagent —an electrophilic acetyl group MeCO+. 

Example 8.1 Propose the retrosynthetic analysis and synthesis of the analsetic paracetamol TM 8.1. 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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