Paracetamol Ciclosporin

Imatinib increases serum tacrolimus levels and is therefore predicted to increase ciclosporin levels. Imatinib may also increases the levels of some benzodiazepines (e.g. midazolam), some calcium-channel blockers (e.g. nifedipine), oestrogens, paracetamol, pimozide, and warfarin. In one case lansoprazole was suspected to have raised imatinib levels. 

A study in rheumatoid arthritis patients taking ciclosporin 2.5 mg/kg daily, found that creatinine clearances were reduced by 3.5% in those taking paracetamol 650 mg four times daily, but this was not considered to be clinically important. ... 

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