Parabolic inhibition noncompetitive

An example for the second (Eq. (6.26)) and the third case (Eq. (6.27)), is also described in Chapter 11 (Section 11.4). It occurs in a Steady-State Ordered Bi Bi system with a dead-end EAP-complex. In this system, the inhibition by the product P is S-parabolic /-linear noncompetitive when the substrate B is variable (and A constant), and the rate equation has the form of Eq. (6.27). The inhibition pattern becomes S-linear /-parabolic noncompetitive, when A is variable (and B constant), and the rate equation takes the form of Eq. (6.26). 

When A is varied, the resulting F term appears in the Intercepti/A function, and when B is the varied substrate, the resulting F term appears in the Slopei/A function. According to the nomenclature of Cleland (Chapter 6 Section 6.6), the system can be described as 6 -hnear, /-parabolic (nonintersecting) noncompetitive inhibition when A is the varied substrate and B is unsaturating, changing to /-linear uncompetitive inhibition when B is saturating. When B is varied, we obtain an -parabolic, /-linear noncompetitive pattern (Fig. 9). 

Parabolic types of inhibition may take several forms. They can be parabolic competitive, 5-linear /-parabolic noncompetitive, 5-parabolic /-linear noncom petitive, or 5-parabolic /-parabolic noncompetitive. The general rate equations for these four types of inhibition are... 

Figttre 7. S-linear /-parabolic noncompetitive inhibition. The data are drawn according to Eq. (6.z6), assuming that the interaction factors are not equal (,a = 3 b = z c = i) and... 

In the preceding chapters, as well as in this chapter, we have encountered a number of different types of inhibitors. The inhibitors have been classified as competitive, uncompetitive, and noncompetitive. Further, the inhibition can be classified as hnear, parabolic, and hyperbolic. Further types of inhibition, which... 

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