Para-chlorophenylethylamine

As detailed in Scheme 1, the intramolecular Heck approach began by protecting para-chlorophenylethylamine (9) as its corresponding trifluoroacetamide 10. lodination of 10 may be achieved in couple of alternatives either with iodine monochloride or with its more sophisticated cousin bis(pyridine)iodonium(I) tetrafluoroborate to furnish iodide 11. Iodide 11 was aUylated to afford 12, which underwent an intramolecular Heck... 

As detailed in Scheme 2, the Friedel-Crafts alkylation approach began by treating para-chlorophenylethylamine (9) with an acyl chloride to provide its... 

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See also in sourсe #XX -- [ , ]

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