Pancuronium structure

Bowman WC, Rodger IW, Houston J, et al. Structure action relationships among some desacetoxy analogs of pancuronium and vecuronium in the anesthetized cat. Anesthesiol 1988 69 57-62. 

Pipecuronium has a long duration of action as compared to pancuronium (up to 2 hours), but is structurally related. It is also 20 to 50 percent more potent than pancuronium and does not produce the adverse cardiovascular effects seen with pancuronium. 

Fig. 1 a-f. Structural formulae of a acetylcholine, b suxamethonium, c tubocurarine, d galla-mine, e alcuronium, and f pancuronium... 

Mongar JL, Whelan RF (1953) Histamine release by adrenaline and d-turbocurarine in the human subject. J Physiol (Lond) 120 146-154 Nana A, Cardan E, Leitersdorfer T (1972) Pancuronium bromide, its use in asthmatics and patients with liver disease. Anaesthesia 27 154-158 Paton WDM (1957) Histamine release by compounds of simple chemical structure. Pharmacol Rev 9 269-328... 

Category 2. Antibodies with recognition profiles confined to the ammonium groups but which cross-react with, and are inhibited almost equally well by, each of the NMBDs with the same or similar groups linked to the nitrogens. Examples include succinylcholine and decamethonium rf-mbocurarine and atracurium and pancuronium and vecuronium. However, since differences occur in the structures attached to the nitrogens in some NMBDs, antibodies to one NMBD, for example, succinylcholine, may not readily cross-react with, and be inhibited by, some other NMBDs, for example, rocuronium. 

Brief early attempts to prepare drug-solid phases for the detection of IgE antibodies to the competitive, non-depolarizing, bulky and structurally rigid aminosteroid NMBDs pancuronium, vecuronium and rocuronium, met with only partial success but with the increasing popularity and use of rocuronium in recent years, a Phadia rocuronium ImmunoCap has been prepared by reacting the drug with succinic anhydride to prepare the hemisuccinate followed by activation to the... 

Fig. 7.9 Two-dimensional and space-fiUing models of the bulky and rigid competitive aminosteroid NMBDs vecuronium, pancuronium, and rocuronium. Note the structural differences of the three compounds at Ri and at R, and R3 for rocuronium. From Baldo BA et al. On the...

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