PAMAM complexes contrast agents

PAMAM dendrimers of generation 5 have also been functionalized with DOTA metal-binding domains and dysprosium complexes investigated as T2 contrast agents. Relaxivity measurements on the dysprosium complexes were interpreted in terms of an inner sphere Curie spin relaxation model with the large temperature dependence suggesting relaxation by a contact interaction effect, with the proton residence time as the primary time constant. The authors beheve that it will be possible to create a new class of T2-selective contrast agents with systems of this type. ... 

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