Palladium Catalyzed Cross Coupling Reactions of Organometallics

Example (see also [27, 28, 29] for other examples) A dehydrovitamin A synthesis  

Similarly, copper and zirconium reagents lead to transmetallation reactions with organopalladium compounds. These reagents are particularly useful to introduce a vinyl group into various substrates and has received applications in steroids [30], prostaglandins (Ref. 31) and natural diterpenes [32, 33] synthesis. 

---

D) Palladium catalyzed cross-coupling reactions of organometallics [26] have been developed to a very valuable S30ithetic tool and have received applications in natural product chemistry the vinylalane case being a particular but useful one as such alanes are readily available by zirconium catalyzed carboalumination of acetylenes. More classical organometallics have also been successfully used for such coupling reactions. 

---