Palladium-catalyzed arylation cross-coupling with organolithium reagents

In 2013, Feringa reported the palladium-catalyzed cross-coupling of organolithium reagents with aryl bromides and chlorides [29]. Pd or Pd° complexes are used associated with bulky electron-rich monophosphines (PfBu, Xphos) or electron-rich NHC ligands (PEPPSI-Ipent) (Scheme 19.24) that favor oxidative additions. 

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