Palladium catalysis Negishi reaction

Negishi, E., King, A. O., Okukado, N. Selective carbon-carbon bond formation via transition metal catalysis. 3. A highly selective synthesis of unsymmetrical biaryls and diarylmethanes by the nickel- or palladium-catalyzed reaction of aryl- and benzylzinc derivatives with aryl halides. J. Org. Chem. 1977,42, 1821-1823. 

The formation of C-C bonds is one of the important fields of synthetic organic chenustry. Modern methods are in the focus of scientists in academia and industry, often being connected to catalysis. Products based on catalysis represent more than 90% of the total amount of new compounds. Presently, palladium-catalysed reactions play a dominant role. For example, Mizoroki-Heck reactions, as well as Stille, Suzuki, Negishi, Kumada and Sonogashira couplings, are in the standard toolbox of organic chemists [1]. 

E. Negishi, T. Takahashi, and K. Akiyoshi, in Catalysis of Organic Reactions, P. N. Rylander, H. Greenfield, and R. L. Augustine, Eds., Mercel Dekker, New York, 1988, 381-407. Aspects of Cross-Coupling Reactions Catalyzed by Palladium and Nickel Complexes. 

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