Palau’imide

Scheme 37 2012OL3862). Treatment of the bromoacetamide 173 with samarium iodide and HMPA followed by diazomethane gives the methyl tetramate 174. The latter intermediate allowed completion of a formal synthesis of palau imide (34). Pettus and coworkers later used this methodolgy in an approach to tetrapetalone (24) (2014OL1294). 

Lan, H.-Q., Ruan, Y.P., and Huang, P.Q. (2010) Hie first enantiosdective synthesis of cytotoxic marine natural prcxiuct palau imide and assignment of its C-20 sterecxhemistry. Chem. Commun., 46, 5319-5321. 

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