Pain, prostaglandins

Pain. Prostaglandins appear to help mediate painful stimuli in a variety of conditions (including inflammation). The compounds do not usually produce pain directly but are believed to increase the sensitivity of pain receptors to mechanical pressure and the effects of other pain-producing substances such as bradykinin.73... 

The inflammatory response. The inflammatory response is another of the body s protective mechanisms. When tissue is damaged by mechanical injury, burns, or invasion by microorganisms, a variety of white blood cells descend on the damaged site to try to minimize the tissue destruction. The result of this response is swelling, redness, fever, and pain. Prostaglandins... 

Wolfram G, Adam O, Zdllner N (1986) Pain, prostaglandins, and food hpids. BiblNutr Dieta 38 112-119... 

Covalent bond (Section 1 3) Chemical bond between two atoms that results from their shanng of two electrons COX 2 (Section 26 6) Cyclooxygenase 2 an enzyme that cat alyzes the biosynthesis of prostaglandins COX 2 inhibitors reduce pain and inflammation by blocking the activity of this enzyme... 

The manner in which salicylates relieve pain and reduce inflammation is not fully understood. It is thought that the analgesic action of the salicylates is due to tiie inhibition of prostaglandins. Prostaglandins are fatty acid derivatives found in almost every tissue of the body and body fluid. Release of prostaglandin is thought... 

Misoprostol is a synthetic prostaglandin E2 analog that exogenously replaces prostaglandin stores. The minimum effective dose shown to inhibit acid secretion and promote mucosal defense is 400 meg/day. Misoprostol use is limited by a high frequency of bothersome gastrointestinal effects such as abdominal pain, flatulence, and diarrhea. In placebo-controlled studies diarrhea occurred with twice the frequency in the... 

Aspirin, non-acetylated salicylates, and other NSAIDs have analgesic, antipyretic, and anti-inflammatory actions. These agents inhibit cyclooxygenase (COX-1 and COX-2) enzymes, thereby preventing prostaglandin synthesis, which results in reduced nociceptor sensitization and an increased pain threshold. NSAIDs are the preferred agents for mild to moderate pain in situations that are mediated by prostaglandins (e.g., rheumatoid... 

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