PAH o-quinone DNA adduct

Two types of covalent PAH o-quinone-DNA adducts are possible. The first type involves the formation of stable covalent adducts that may result from either 1,4- or 1,6-Michael addition of the N2-exocyclic amino group of dGuo or the N exocyclic amino group of dAde. Evidence exists for these adducts in reactions of B [a] P-7,8-dione with either deoxyribonucleosides or bulk DNA [94, 95]. In the former case,... 

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