Pacifigorgia adamsii

Three new sesquiterpenes named valerenenol (517), isovalerenenol (518), and anhydrovalerenenol (519) from an unidentified Okinawan soft coral are based on the bicarbocyclic carbon skeleton of e /-valeren-ane 413) and pacifigorgiol (520) is a related sesquiterpene from Pacifigorgia adamsii 414). The structure of 520 which showed modest activity as a fish toxin was established by a combination of spectral and X-ray crystallographic techniques and was confirmed by an eleven step synthesis 415). 

IzAC, R.R., S.E. Poet, W. Fenical, D. van Engen, and J. Clardy The Structure of Pacifigorgiol, an Ichthyotoxic Sesquiterpenoid from the Pacific Gorgonian Coral Pacifigorgia cf. adamsii. Tetrahedron Lett. 23, 3743 (1982). 

The carbon skeleton of valerenane is represented by valerenenol, isolated from an undetermined species of Xenia harvested in Japan, and an isomer carbon skeleton is represented by pacifigorgiol, isolated the same year from the gorgonacean Pacifigorgia cf adamsii (Kobayashi et al, 1982b Izac et al, 1982a). These derivatives are ichthyo-toxic. Sinularianin B is a recent new example of the... 

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