P-Methoxyphenacyl bromide

Polycarpamines A-E (137-141) are unusual sulfur-containing antifungal agents from Polycarpa auzata from the Philippines. The structures were elucidated by interpretation of spectral data [148]. Polycarpine (142), a cytotoxic, dimeric, disulfide alkaloid, the corresponding dihydrochloride (143) and two sulfur-containing related monomers (144-145) were isolated from Polycarpa clavata from Western Australia [149]. Polycarpine (142) was also isolated with two monomers (144,146) from P. auraia from Chuuk [150] and later it was synthesised in three steps from p-methoxyphenacyl bromide [151]. 

Methylphthalazine (146) with p-methoxyphenacyl bromide apparently gave only 2-(p-methoxyphenacyl)-4-methylphthalazin-2-ium bromide (147) and thence, by treatment with potassium carbonate, p-methoxybenzoyl(4-methylphthalazin-2-io)methanide (148) (for details, see original). " ... 

Me ether [2632-13-5]. 2-Bromo-4 -methyoxyacetophenone. 2-Bromo-1 - 4-metho.xyphenyl)ethanone, 9CI. p-Methoxyphenacyl bromide QH Brbj M 229.073... 

Other phenacyl reagents are p-bromophena-cyl bromide, or a-bromo-p-bromoacetophenone, p-chlorophenacyl bromide, or a-bromo-p-chloroace-tophenone, p-nitrophenacyl bromide, or a-bromo-p-nitroacetophenone, m-methoxyphenacyl bromide, or o-bromo-3-methoxyacetophenone. 

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