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P-Isopropylmalate

P-isopropylmalate dehydrogenase, catalyzes the third step in the leucine biosynthesis pathway... [Pg.332]

Another new alkaloid (50) was also isolated from P. heterophylla. Mild acid hydrolysis of (50) gave a desacetyl compound which showed a prominent peak due to the loss of —CH2C02CH3 in its mass spectrum, thereby indicating that the other carboxyl group is esterified to the base. Vigorous acid hydrolysis of (50) gave 1-hydroxymethylpyrrolizidine of undefined stereochemistry together with a neutral compound which yielded (-)-2-isopropylmalic acid on basic hydrolysis. [Pg.51]

Isopropylmalate isomerase (Leu biosynthesis) a-Isopropyl malate/a-hydroxy-P-carboxy-i socaprate... [Pg.213]

Figure 5 Structures of 2R,35-isocitrate (A), 2/ ,3S-isopropylmalate (B), and 2R,3S-homoisocitrate (C). a, P refers to the a- and fi-carboxyl groups, respectively. The unique y-moieties are presented in bold. Figure 5 Structures of 2R,35-isocitrate (A), 2/ ,3S-isopropylmalate (B), and 2R,3S-homoisocitrate (C). a, P refers to the a- and fi-carboxyl groups, respectively. The unique y-moieties are presented in bold.
Figure 6 Schematic diagram of the active site of the E. coli NADP-IDH with bound 2A,3>S-isocitrate (A) and the active site of T. thermophilus NAD-IMDH with bound 2R,3S-isopropylmalate (B). A prime indicates the residues donated from the second subunit, a, 3 refers to a- and P-carboxyl groups, respectively. The major determinants of substrate specificity are residues Seri 13 and Asnll5 in the NADP-IDH, and Glu87 and Leu90 in the NAD-IMDH, which interact with the unique y-moieties of the substrates. (Modified from Ref. 15.)... Figure 6 Schematic diagram of the active site of the E. coli NADP-IDH with bound 2A,3>S-isocitrate (A) and the active site of T. thermophilus NAD-IMDH with bound 2R,3S-isopropylmalate (B). A prime indicates the residues donated from the second subunit, a, 3 refers to a- and P-carboxyl groups, respectively. The major determinants of substrate specificity are residues Seri 13 and Asnll5 in the NADP-IDH, and Glu87 and Leu90 in the NAD-IMDH, which interact with the unique y-moieties of the substrates. (Modified from Ref. 15.)...
Both NADP-IDH and the homologous isopropylmalate dehydrogenase (IMDH, EC 1.1.1.85) belong to the non-Rossmann-fold p-decarboxylating dehy-... [Pg.556]

Biosynthesis Leu is formed from pyruvic acid - 2-acetolactic acid [acetolactate synthase (EC 4.1.3.18.)+(l-hydroxyethyl)-TPP] - 2,3-dihydroxy-isovaleric acid [reductase+NAD(P)H] - 2-oxoisova-leric acid [dihydroxyacid dehydratase] - 2-isopropyl-malate [2-isopropylmalate synthase + acetyl-CoA (EC 4.1.3.12)] -> 3-isopropylmalate [isopropylmalate dehydratase (EC 4.2.1.33) -HjO+HiO] 2-oxo-isocaproate [3-isopropylmalate dehydrogenase (EC 1.1.1.85) + NAD ] L. [leucine aminotransferase (EC... [Pg.355]

Further examples of foe synthesis of derivatives of (2R,3 3-isopnqi iiialic add as potential inhibitors of isopropylmalate dehydrogenase by foe carbohydrate template method described in Vol. 27, p. 177, ref 49 have been reported. ... [Pg.195]

P-leuA (WT) Isopropylmalate synthase TACCCA TTGTATGCTTC - Patek et al. (2003b)... [Pg.215]

See other pages where P-Isopropylmalate is mentioned: [Pg.540]    [Pg.142]    [Pg.412]    [Pg.419]    [Pg.587]    [Pg.72]    [Pg.540]    [Pg.142]    [Pg.412]    [Pg.419]    [Pg.587]    [Pg.72]    [Pg.225]    [Pg.362]    [Pg.455]    [Pg.110]    [Pg.469]    [Pg.459]    [Pg.1147]    [Pg.418]   
See also in sourсe #XX -- [ Pg.428 ]



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Isopropylmalate

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