P-chloroacetophenone oxime

A. (o-Bromo-p-chloroacetophenone oxime. A 500-mL, four-necked, round-bottomed flask equipped with a dropping funnel (closed with a giass stopper), mechanicai stirrer, drying tube (calcium chioride, CaCij), and a thermometer is charged with p-chloroacetophenone (38.6 g, 0.25 moi), glacial acetic add (220 mL) and aqueous hydrobromic acid (HBr) [1 mL, 48 % (w/w). Note 1]. The flask is immersed in a water bath (15°C, Note 2) and bromine (40.0 g, 0.25 mol) is added from the dropping funnei at such a... 

Drying lo-bromo-p-chloroacetophenone oxime was carried out in the dark since otherwise this material turns pink in light. Wrapping the flask with )luminum foil provides adequate light protection for this purpose. 

M-Bromo-p-chloroacetophenone oxime Ethanone, 2-bromo-1-(4-chlorophenyl)-oxime (12) (136978-96-6)... 

Recently, Suzuki-type reactions in air and water have also been studied, first by Li and co-workers.117 They found that the Suzuki reaction proceeded smoothly in water under an atmosphere of air with either Pd(OAc)2 or Pd/C as catalyst (Eq. 6.36). Interestingly, the presence of phosphine ligands prevented the reaction. Subsequently, Suzuki-type reactions in air and water have been investigated under a variety of systems. These include the use of oxime-derived palladacycles118 and tuned catalysts (TunaCat).119 A preformed oxime-carbapalladacycle complex covalently anchored onto mercaptopropyl-modified silica is highly active (>99%) for the Suzuki reaction of p-chloroacetophenone and phenylboronic acid in water no leaching occurs and the same catalyst sample can be reused eight times without decreased activity.120... 

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