P-chiral phosphoro-acetates

a series of racemic phosphinylacetates, phosphonylacetates and phos-phorylacetates were resolved into enantiomers via their PLE-promoted hydrolysis to give products in high yields and with high ees (Equation 33). The most representative, selected examples are collected in Table 7. 

The same methodology was applied to the desymmetrization of prochiral phenylphosphinyldiacetate 72. As a result, the monoester 73 was obtained in good yield but with moderate ee (Equation 34).  

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