P-Amino acids cyclization

Scheme 99 Synthesis of P-lactam by P-amino acid cyclization...

P-Lactams from P-amino acids.1 p-Amino acids cyclize to p-lactams on treatment with (C6H5)2P(0)C1 and triethylamine (1 1) in CH,CN at 80° usually with preservation of the stereochemistry of the amino acid. However, yields are rather low when the amino group is primary. 

---