P-Acetamidophenol

Inclusion of the carbon atoms of an aromatic ring in the side chain sequence is apparently quite consistent with antlmalarial activity. Thus, reaction of p-acetamidophenol with formaldehyde and diethylamine affords the Mannich product, 79. This is then converted to the diamine (80) by saponification. Alkylation with the chloroquinoline, 70, affords amidoquine (81). The same sequence starting with the Mannich product in which pyrrolidine has been used as the amine (82) gives amopyroquine (83). 

Another series of monomers that was prepared began with the displacement of an unactivated aryl halide with phenate anion in the presence of a copper catalyst [113-115], Figure 46 outlines the basic route followed for the preparation of 114a. The sequence of reactions started with 4-bromobenzocyclobu-tene, 2 which was reacted with the phenate of p-acetamidophenol, 112a in the presence of copper (I) chloride as a catalyst, to afford the ether linked product 113a in a yield of 50-75%. 

SYNS ABENSANIL ACAMOL ACETAGESIC ACETALGIN p-ACETAMIDOPHENOL 4-ACETAMIDOPHENOL ACETAMINOPHEN p-ACETAMINOPHENOL N-ACETYL-p-AMINOPHENOL... 

ACETAMIDOPHENOL see HIMOOO p-ACETAMIDOPHENOL see HIMOOO 2-ACETAMIDO-5-SULFONAMIDO-1,3,4-THIADIAZOLE see AAI250... 

Synonyms APAP 4 -Hydroxyacetanilide p-Hy-droxyacetanilide Acetamide N-(4-hydroxyphenyl) N-Acetyl-p-aminophenol N-Acetyl-p-aminophe-nol p-Acetamidophenol 4-Acetamidophenol 4-Acetaminophenol Paracetamol Tylenol Chemical/Pharmaceutical/Other Class Acetaminophen is a synthetic nonopioid congener of acetanilide in the p-aminophenol class Chemical Eormula C8H9NO2... 

In order to avoid citation of difficult chemical names, generic names came into being. However, in the beginning different names were independently assigned to the same substance in different countries. For example, not everybody would know that acetaminophen, 7V-(4-hydroxyphe-nyl)acetamide, 4 -hydroxyacetanilide, p-acetamidophenol, A -acetyl-p-aminophenol, acetomenophen and paracetamol are the same substance (see Fig. 41.2). 

Synonyms. Paracetamol N-(4-Hydroxyphenyl) acetamide p-Acetamidophenol p-Acetylaminophenol N-Acetyl-p-aminophenol Calpol Tylenol APAP. 4.8.2.S Theory... 

Acetamidophenol p-Acetamidophenol. See4-Acetaminophenol 4-Acetamidophenyl salicylate. See Acetaminosalol... 

CAS 103-90-2 EINECS/ELINCS 203-157-5 Synonyms 4-Acetamidophenol p-Acetamidophenol Acetaminophen p-Acetaminophenol N-Acetyl-4-aminophenol APAP 4-Hydroxyacetanilide p-Hydroxyacetanilide 4-Hydroxyphenylacetamide N-(4-Hydroxyphenyl) acetamide Paracetamol... 

Preparation of acetaminophen involves treating an amine with an acid anhydride to form an amide. In this case, p-aminophenol, the amine, is treated with acetic anhydride to form acetaminophen (p-acetamidophenol), the amide. 

Among drugs introduced in the nineteenth century, chloral hydrate (3.21) is reduced in the body to trichloroethanol (3.22) which is also hypnotic (Butler, 1948) and acetanilide (3.23) and phenacetin 3.24) acts as analgesics after metabolism to p-acetamidophenol (3,6) which has now replaced these pro-drugs (Brodie and Axelrod, 1948, 1949). An old suggestion that codeine exerts some of its analgesic effect after demethyla-tion to morphine has been confirmed (Adler, 1963). 

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