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P-A-acetylhexosaminidase

Scheme 2 Hydrolysis mechanisms of retaining (A) and inverting (B) glycosidase and P-A-acetylhexosaminidase, which uses a modified retaining mechanism (C). Scheme 2 Hydrolysis mechanisms of retaining (A) and inverting (B) glycosidase and P-A-acetylhexosaminidase, which uses a modified retaining mechanism (C).
Scigelova M, Crout DHG. Microbial P-A-acetylhexosaminidases and their biotechnological applications. Enzyme Microb. Tech-nol. 1999 25 3-14. [Pg.419]

Kadowaki S, Saskiawan I, Watanabe J, Yamamoto K, Bunno M, Ichihara Y, Kumagai H. Transglycosylation activity of P-A-acetylhexosaminidase from Penicillium oxalicum and its application to synthesis of a drug carrier. J. Perm. Bioeng. 1997 83 341-345. [Pg.419]

Uzawa H, Zeng X, Minoura N. Synthesis of 6 -sulfodisaccharides by P-A-acetylhexosaminidase-catalyzed transglycosylation. Chem. Commun. 2003 34 100-101. [Pg.419]

Tay-Sachs disease can be diagnosed in the course of fetal development. Amniotic fluid is obtained by amniocentesis and assayed for P-A-acetylhexosaminidase activity. [Pg.1068]

The vertebrate hyaluronidases, previously neglected enzymes [185], are all endo-P-A-acetylhexosaminidases employing substrate hydrolysis as their mechanism of action. These hydrolases have, until recently, been difficult to assay. Turbidometric and... [Pg.825]

Tay-Sachs disease A genetic disease that is a result of a deficiency in hexosaminidase A (P-A-acetylhexosaminidase), an enzyme that is involved in the degradation of ganghosides in the lysosome. The disease is prevalent in Jewish children of Eastern European descent and leads to a buildup of ganghoside in nerve cells of the brain and neuronal dysfunchon. [Pg.255]

C. Tay-Sachs disease is the result of the lack of the enzyme p-A-acetylhexosaminidase. Affected infants show weakness and retarded motor skills before 1 year of age. Other abnormalities follow, and death usually occurs before age 3. [Pg.260]

The synthesis of 2-acetamido-4-0-(2-acetamido-2-deoxy-P-D-galactopyranosyl)-2-deoxy-D-glucopyranose using P-A -acetylhexosaminidases from Asperigillus oryzae and Jack bean with a p-nitrophenyl activated donor [23] (Figure 12.8). [Pg.402]

Singh, S., R. Gallagher, P. J. Derrick, and D. H. G. Crout. 1995. Glycosidase-catalyzed oligosaccharide synthesis Preparation of the A-acetylchito-oligosaccharides penta-A/-acetylchitopentaose and hexa-Al-acetylchitohexaose using the P-A-acetylhexosaminidase of Aspergillus oryzae. Tetrahedron Asymm. 6 2803-2810. [Pg.147]

The transglycosylation activity and the reverse hydrolytic activity of A. oryzae P-A-acetylhexosaminidase have been used to synthesize A-acetylchitooligosaccharides... [Pg.1611]

K. Yamashita, T. Ohkura, H. Yoshima and A. Kobata, Substrate specificity of diplococcal P-A-acetylhexosaminidase, a useful enzyme for the structural studies of complex type asparagine-linked sugar chain. Biochem. Biophys. Res. Commun., 1981,100, 226-232. [Pg.1619]


See other pages where P-A-acetylhexosaminidase is mentioned: [Pg.314]    [Pg.320]    [Pg.320]    [Pg.320]    [Pg.321]    [Pg.236]    [Pg.405]    [Pg.828]    [Pg.259]    [Pg.260]    [Pg.1611]    [Pg.1611]   
See also in sourсe #XX -- [ Pg.393 ]

See also in sourсe #XX -- [ Pg.393 ]




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