P2 selective antagonists

P2-selective antagonists, if specific enough, would be useful as research tools to delineate the role p2-adrenoceptors play in greater detail even though presently no clinical applications for such compounds are apparent. The first compound to have this property was oc-methyl DCI. 

Computer analysis of [ I]iodocyanopindolol competition studies using the relatively selective pi-adrenoceptor antagonist, ICI 89406, and the P2-selective antagonist, ICI 118551, on rabbit arterial blood mononuclear leucocyte plasmalemmal preparations favoured a two-site model indicating that both Pi- and Pj-adrenoceptor subtypes were present in approximately equal numbers (Tenner jr. et al. 1989). 

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