Oxygen scavenging protection model

Figure 10.5 Oxygen scavenging protection model of EB on the exposed steel at coating defect [73],...

Low bone density is also associated with oxidative stress in lower species. Thus, in ovariectomized rats melatonin has a bone-protective effect, which depends in part on its free radical-scavenging properties (Cardinali et al., 2003). A mouse model that has been used to study the role of ROS in age-related disorders including osteoporosis is the accelerated mouse-senescence-prone P/2 (SAM-P/2) that generates increased oxygen radicals (Hosokawa, 2002 Udagawa, 2002). This model could be very useful in studying the role of lycopene in osteoporosis. 

In a rat model of hemolysis (by glycerol injection) iron released from hemoglobin resulted in hydroxyl radical formation, lipid peroxidation and renal dysfunction. Desferrioxamine (DFO), which binds free iron could protect against injury [243]. LLC-PKj, OK and NHK-C cells respond to injury mediated by reactive oxygen molecules with an early decline in ATP levels and a late response consisting of cell detachment and cell lytic injury. Scavengers of hydroxyl radicals and iron chelators prevented these alterations [246]. 

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