Oxygen cytochrome P450, methane

Non-heme iron-containing monooxygenases, such as methane monooxygenase and o-hydroxylase, analogously to cytochrome P450, can transfer the oxygen atom from molecular oxygen to the C-H bonds of alkanes [24],... 

This mechanism is reminiscent of the oxygen rebound mechanism proposed for cytochrome P450 and which may also be operative in methane monooxyenase. The difference, however, is that in Mechanism 3 two (as opposed to one) oxygens are inserted in a C-H bond. 

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