Somnolence oxycodone

Comparative studies In 14 patients using controlled-release oxycodone for postoperative pain and nine using patient-controlled morphine, there was a lower incidence of postoperative nausea and vomiting with oxycodone (14% versus 20%) [135 ]. There was no somnolence, respiratory depression, confusion, or pruritus in either group. 

Pregabalin The combination of controlled-release oxycodone with pregabalin reduced the incidence of somnolence associated with oxycodone in 169 patients compared with 106 on oxycodone alone [145 ]. 

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