Oxycodone Rifampicin

Rifampicin markedly increases the metabolism of codeine and morphine, and reduces their effects. Rifampicin dramatically reduced the effects of oxycodone in one patient. 

A 60-year-old man who was taking rifampicin as well as oxycodone had 3 consecutive negative urine oxycodone screens in a 2-month period, which would normally suggest that he was not taking the oxycodone. However, oxycodone metabolites were found in his urine confirming compliance with his medication. An interaction between rifampicin and oxycodone was suspected and his oxycodone dose was increased to optimise his pain control. ... 

Rifampicin Rifampicin induces CYP3A and significantly reduces the plasma concentrations of both oral and intravenous oxycodone, as reported following a study in 12 healthy volunteers who took rifampicin 600 mg for 7 consecutive days [158. The pharmacological effects of oxycodone were reduced. The dose of oxycodone should be adjusted when rifampicin is coadministered. 

Drug-drug interactions Rifampicin Rifam-picin reduced the therapeutic effect of oxycodone by inducting CYP3A in 12 healthy volunteers [140 ]. 

Oxycodone Oxycodone is metabolized maiiily in the hver by CYP3A and CYP2D6, which rifampicin induces. The interaction of rifampicin 600 mg/day for 7 days with a single dose of oxycodone, 0.1 mg/kg intravenously or 15 mg orally, has been studied in a four-session, paired, placebo-controlled crossover study in 12 volunteers [86 ]. Concentrations of oxycodone and its metabolites noroxycodone, oxymorphone, and noroxymorphone were determined for 48 hours. Psychomotor... 

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