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2-oxo-clopidogrel

Figure 20.5 Metabolic activation of clopidogrel (12) in humans. A small part of a dose is activated by CYP3A to 2-oxo-clopidogrel (13), followed by hydrolytic ring opening to the active agent, a highly reactive thiol metabolite (14) that irreversibly antagonizes platelet ADP receptors via a covalent S-S bridge [31, 32]. Figure 20.5 Metabolic activation of clopidogrel (12) in humans. A small part of a dose is activated by CYP3A to 2-oxo-clopidogrel (13), followed by hydrolytic ring opening to the active agent, a highly reactive thiol metabolite (14) that irreversibly antagonizes platelet ADP receptors via a covalent S-S bridge [31, 32].
Clopidogrel and its thiolactone metabohte, 2-oxo-clopidogrel, both inactivate human CYP2B6 in a time- and concentration-dependent... [Pg.212]

Fig. 5.16 The pathway for the bioactivation of clopido-grel by P450s Clo, clopidogrel 2 oxo, 2-oxo-clopidogrel. The numbers shown in the structure of the active metabolite (AM) indicate the numbering of the two chiral centers... Fig. 5.16 The pathway for the bioactivation of clopido-grel by P450s Clo, clopidogrel 2 oxo, 2-oxo-clopidogrel. The numbers shown in the structure of the active metabolite (AM) indicate the numbering of the two chiral centers...
See other pages where 2-oxo-clopidogrel is mentioned: [Pg.2]    [Pg.60]    [Pg.3]    [Pg.3]    [Pg.564]    [Pg.736]    [Pg.736]    [Pg.212]    [Pg.213]    [Pg.213]    [Pg.2]    [Pg.60]    [Pg.3]    [Pg.3]    [Pg.564]    [Pg.736]    [Pg.736]    [Pg.212]    [Pg.213]    [Pg.213]   
See also in sourсe #XX -- [ Pg.2 ]

See also in sourсe #XX -- [ Pg.2 ]



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Clopidogrel

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