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Oximes carboxylesterase reactivation

Maxwell, D.M., Lieske, C.N., and Brecht, K.M., Oxime-induced reactivation of carboxylesterase inhibited by organophosphoms compounds, Chem. Res. Toxicol., 7,428, 1994. [Pg.224]

Certain oximes, such as bispyridinium oxime HI 6 and 2-PAM, have been reported to protect against soman toxicity. Pretreatment with HI 6 (50 mg/kg) together with atropine (10 mg/kg) increased the LC50 (LC50 X time) in rats by a factor of 7 (Schoene et al. 1985). HI 6 is an effective reactivator of soman-inhibited acetylcholinesterase. Its protective action was found to be greater in mice than in guinea pigs (Maxwell and Koplovitz 1990). In addition to reactivation of the enzyme acetylcholinesterase inhibited by soman, HI 6 produced an effect on carboxylesterase that... [Pg.680]

See other pages where Oximes carboxylesterase reactivation is mentioned: [Pg.199]    [Pg.217]    [Pg.442]    [Pg.762]    [Pg.178]    [Pg.140]    [Pg.824]    [Pg.87]   
See also in sourсe #XX -- [ Pg.1035 , Pg.1036 ]



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Oxime reactivators

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Reactivators carboxylesterase

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