Oxidized 2,7-seco Aspidospermidine Derivatives

These bases may well be artifacts of the isolation process, derived by the oxidation of a precursor, possibly 1,2-didehydroaspidospermidine (27). New sources of rhazinilam (67) have been reported (5,59,82-84), and its 

21- dihydro derivative 68 has been found in Leuconotis eugenifolius A. DC (82). The latter suffers oxidation on prolonged exposure to air, with formation of rhazinilam. Further oxidation of rhazinilam affords 3-0X0-14,15-didehydrorhazinilam (69), which has been obtained from cell suspension cultures of A. quebrachoblanco (53), and further oxidation of 

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