Oxidized LDL - Is It a Reality

There is now strong evidence that LDL oxidation does indeed occur in vivo (see later) and strong clinical validation of the oxidation hypothesis has been achieved. The 

given the evidence, there is strong experimental and epidemiological support for the oxidized LDL hypothesis. 

The author thanks the British Heart Foundation, St Thomas s Trustees, the Ministry of Agriculture, Fisheries and Food, the British Technology Group and Bioxytech-Paris for supporting the research of her group. 

Agamah, E.S., Srinivasan, S.R., Webber, L.S. and Berenson, G.S. (1991). Serum uric acid and its relation to cardiovascular disease risk factors in children and young adults from a biorac-ical community The Bogalusa Heart Study. J. Lab. Clin. Med. 113, 241-249. 

Andrews, B., Rice-Evans, C., Paganga, G., Leake, D., Bumand, K., Browse, N., Sommerville, K. and Taub, N. (1994). Oxidisability of low density lipoproteins in patients with carotid or femoral atherosclerosis. Atherosclerosis (in press). 

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