Oxidation of Alkynes Involving No Bond Cleavage

As with alkenes we consider first those oxidations which do not cleave the acetylenic bond giving a-diketones, or oxidation of alkynyl amines and ethers to a-keto amides and esters, and then consider oxidative alkyne cleavage to acids. 

CjjjH j with R =CH OAc. Use of such a pH and low temperature avoids 

As a part of research on the immnnosnppresant rapamycin it was found that acetylenic amides derived from diethylamine and proline gave the corresponding amide-diones with RuO /aq. Na(10 )/CCl -CH3CN [287]. 

2 Alkynyl Amines and Ethers to a-Keto Amides and Esters 

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