Oxazolidinones, as chiral auxiliaries for

Li and co-workers developed a novel asymmetric halo aldol reaction using Evans oxazolidinones as chiral auxiliaries for tandem I-C/C-C bond formations. This reaction provides a practical approach to a variety of halo aldols of a non-Evans type that cannot be easily prepared by other methods. Excellent diastereoselectivity (> 95% de) and yields (80-93%) have been obtained. This reaction can be considered as a Lewis acid (Et2Al-I)-promoted Morita-Baylis-Hillman (MBH) process. 

Several reports gave account of the successful employment of chiral oxazolidinones as chiral auxiliaries. For example, they were used to direct, with a proper stereocontrol, the synthesis of modified amino acids (13BJ02009) and iso-fatty acids (13BJO1807) in one case, they were used to control a torquoselective Nazarov cyclization that yielded a precursor of the natural compound (+)-pauci lorol F (130L4118). 

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