Oxazoles copper® trifluoromethanesulfonate

Decomposition of the diazoacetic ester (548) to the keto carbene (549) is promoted by copper(II) trifluoromethanesulfonate. In the presence of nitriles, 1,3-dipolar addition to the nitrile occurred giving the oxazole (550) (75JOM(88)ll5) (see also Section 4.03.8.1). 

Nagayoshi K. and Sato T. (1983) One-step synthesis of oxazoles from ketones and nitriles using copper(II) trifluoromethanesulfonate as a key reagent Chem Lett. 1355-1356. 

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See also in sourсe #XX -- [ , ]

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