Oxaliplatin extravasation

Two other cases of oxaliplatin extravasation have been reported (233). Both occurred when the intraport needle disconnected. The initial symptoms were swelling and tenderness at the port site. The patients developed severe inflammation after 3 days. Treatment included local cool packs, diclofenac ointment, and oral indometacin, morphine, or dexamethasone. The authors avoided saline instillation because sodium chloride and oxaliplatin may be incompatible in combination (119). Both patients recovered without any sign of local necrosis and longterm sequelae (233)... 

Accidental subcutaneous administration of oxaliplatin resulted in a red-brown painful swelling and sclerosis of the skin within 8 days (232). The symptoms were worst 1 week after extravasation and lasted for about 5 weeks, but the patient, a 52-year-old woman, recovered fully. Acute intervention included local fluid instillation to dilute the extravasation, removal of the cannula, cold packs, and a gel containing aescin and diethylamine salicylate. 

Baur M, Kienzer HR, Rath T, Dittrich C. Extravasation of oxaliplatin (Eloxatin ) - clinical course. Onkologie 2000 23(5) 468-71. 

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See also in sourсe #XX -- [ ]

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