Oxadiazolones, synthesis

In contrast to (74), compounds (75) are easily hydrolyzed to amidoximes. IV(4)-Alkylation of oxadiazolones (74) by oxiranes has been used for a synthesis of oxadiazines <75CBi9ll>. 

Synthesis, Insecticidal Activity, and Anticholinesterase Activity of Some Oxadiazolones... 

This report summarizes the synthesis, insecticidal activity, and anticholinesterase activity of some novel N-dihydrobenzo-furanyl oxadiazolones. The compounds were primarily aphicides with reduced activity on houseflies, corn earworms and two-spotted spider mites. Some of these gompounds were potent anticholineterases (I-. values 1-10x10 M) that were slowly reversible. There was little relationship between in vitro... 

The synthesis of these molecules can be broken down Into two parts. The first segment consisted of preparation of the dihydrobenzo-furanylhydrazines from which the oxadiazolones were eventually prepared. These hydrazines were prepared as follows the ap-... 

This report briefly summarizes the synthesis, insect toxicity and anticholinesterase activity of some novel dihydrobenzofuranyl oxadiazolones, a class of insecticides whose major strength lies in their toxicity to aphids with reduced activity on houseflies, two-spotted spider mites and corn earworms. This is similar to the previously reported RP 32,861, which also was most active on sucking insects. The molecule with the broadest toxicity spectrum... 

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