Ovotransferrin amino acid sequence

The large size of transferrins (670-700 residues), with the consequent difficulties of chemical sequencing, meant that it was not until 1982 that the first amino acid sequences, those of human serum transferrin 10) and chicken ovotransferrin 34,35), were established. These were closely followed by that of human lactoferrin 11). The twofold internal repeat in each sequence (see below) was immediately apparent, and comparison of all three sequences then identified conserved tyrosines and histidines that were potential ligands for iron (11). 

---