Outside-in signaling

Fig. 1 Downstream effects of integrin activation during outside-in signalling. The ECM properties and the growth factor environment regulate assembly of the ECM-integrin-adhesome-F-actin system, which controls cell activity. The long-term effects of the outside-in signalling (10-60 min) are indicated in italics...

Figure 2 Integrin receptors relay signals from ECM to regulate a wide spectrum of cellular processes, including migration, cell cycle, survival, and cell differentiation. (Please see text for details of the outside-in signaling of integrins.)...

Rho family proteins serve as important mediators for integrin outside-in signaling. Integrin clustering and focal complex... 

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