Other Thoughts

At one level, the analytical value of ion mobility depends only on a result that discloses details of the composition of a sample useful to a user. Mobility measurements today are being used to link ion structure and mobility of biomolecules through a blend of computational modeling and biological activity of the original substances. Quite apart from questions concerning the relationships between a molecule in solution and a gas phase ion derived from this molecule, the very first step of linking drift time and ion collision cross section to some structure must be advanced in concept, practice, and examples. 

The comparison of mobility results between laboratories or between instruments is today not controlled, and this has animated the development of chemical standards as described. Establishing international protocols and then testing these protocols for qualitative and quantitative suitability is a distant thought in this generation of users or developers of ion mobility methods. 

Finally, the long-standing limitation of ion mobility instruments as point sensors with all the limitations may be solvable with multiple instruments either distributed through some area or region or on airborne platforms in motion. This has been demonstrated with the unmanned airborne vehicle (UAV) work of C. S. Harden and colleagues and could develop with reduced size and cost of ion mobility analyzers and UAVs. 

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The original writings of Hippocrates and his school have not been handed down to us. They reached Alexandria around 300 BC and were summarized by the Roman author Celsus in the first century AD. The need for individual adaptation of each therapy was stressed here frightened patients are to be reassured in a friendly manner manic patients should be chained and perhaps starved music and poetry lift the melancholy the mad should be shunned or brought to other thoughts by sudden noises and adequate sleep should be ensured for all patients. Poppy (opium) and henbane were available for this, but rippling fountains could also have a calming and soporific action. 

Then she answered, you shall know no more until you have deserved it. Alas, said I, then O dear Lady, will you tell me the way how I may deserve it. For I will always serve you loyally without any other thought. I cannot make you recompense, nor increase your riches. I will serve you incessantly, if you will give me so noble a gift, as to receive me for one of yours. 

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